Mavacamten (MYK-461
MYK-461
CAS: 1642288-47-8
Molecular Formula: C15H19N3O2
Mavacamten (MYK-461 - Names and Identifiers
| Name | MYK-461 |
| Synonyms | MYK461 MYK-461 SAR-439152 Mavacamten (MYK-461 2,4(1H,3H)-Pyrimidinedione, 3-(1-methylethyl)-6-[[(1S)-1-phenylethyl]amino]- |
| CAS | 1642288-47-8 |
Mavacamten (MYK-461 - Physico-chemical Properties
| Molecular Formula | C15H19N3O2 |
| Molar Mass | 273.33 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| pKa | 8.83±0.40(Predicted) |
| Storage Condition | -20℃ |
Mavacamten (MYK-461 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
Mavacamten (MYK-461 - Uses and synthesis methods
biological activity
Mavacamten (MYK-461, SAR439152) is a small molecule regulator of myocardial myosin (cardiac myosin), which regulates hyperganglionic contraction in hypertrophic cardiomyopathy.
in vitro studies
MYK-461 reduces the activity of steady-state ATPase by inhibiting the phosphate release rate of β-cardiac myosin-S1. The MYK-461 regulates multiple steps in the myosin chemomechanical cycle: In addition to reducing the rate-limiting step in the cycle (phosphoric acid release),MYK-461 also reducing the number of myosin-S1 heads (myosin-S1 heads can interact with actin filaments when the weak binding state transitions to the strong binding state). MYK-461 also reduces the rate of myosin binding to ADP-actin and the rate of ADP release from myosin-S1.
In vivo studies
In a mouse model transplanted with myosin heavy chains containing human heterozygous mutations, early and long-term MYK-461 administration (MYK-461) can inhibit the development of ventricular hypertrophy, myocardial cell disorder and myocardial fibrosis, and reduce the expression of hypertrophy and fibrosis-related genes.
Last Update：2024-04-10 22:41:30
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Product Name: (S)-3-Isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione Request for quotationCAS: 1642288-47-8
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CAS: 1642288-47-8
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Email: 3008007409@qq.com
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